Diabetes Care. 1989 Jan;12(1):67-74. Aspartame metabolism in normal adults, phenylketonuric heterozygotes, and diabetic subjects. Filer LJ Jr, Stegink LD. Department of Pediatrics, College of Medicine, University of Iowa, Iowa City 52242. This study reviews clinical studies testing the effects of various doses of aspartame on blood levels of phenylalanine, aspartate, and methanol in normal subjects and known phenylketonuric heterozygotes. The effect of aspartame on the phenylalanine-to-large neutral amino acid ratio under various feeding situations is shown. The clinical studies of aspartame in diabetic subjects are limited to observations of its effects on blood levels of glucose, lipids, insulin, and glucagon. These studies clearly demonstrate the safety of this high-intensity sweetener for use by humans.
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